abstract：OBJECTIVE:To investigate the clonal characteristics of B cells in the synovial membranes of rheumatoid arthritis (RA) patients. METHODS:The clonality of B cells at separate sites of the synovial membrane and other tissues from RA patients were investigated by a reverse transcriptase-polymerase chain reaction with a VH...

journal_title：Scandinavian journal of rheumatology

authors： Shiokawa S,Matsumato N,Nishimura J

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Association with human leukocyte antigen (HLA)-DRB alleles, implicated in the aetiopathogenesis of rheumatoid arthritis (RA), is found to be different in various ethnic groups. This study aimed to investigate DRB1 alleles in RA patients in Turkey, and to examine the effect of these alleles on disease severity...

journal_title：Scandinavian journal of rheumatology

authors： Kinikli G,Ateş A,Turgay M,Akay G,Kinikli S,Tokgöz G

更新日期：2003-01-01 00:00:00

abstract：:Ultrasound detects effusion and synovial proliferation caused by synovitis. The study was undertaken to evaluate the signs of synovitis in patients with primary Sjögren's Syndrome (SS). Joint effusion was detected and synovial thickness was measured in the suprapatellar synovial bursa. Results have been compared with ...

journal_title：Scandinavian journal of rheumatology

authors： Iagnocco A,Coari G,Palombi G,Valesini G

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of TNF blocking therapy on synovial immune activity in rat adjuvant arthritis (AA) by measuring mRNA expression of key macrophage and T cell cytokines during PEG sTNF-RI treatment (10mg/kg) on days 8, 10 and 12. METHODS:Paw volume was assessed every 3-4 days. Ankles were removed fo...

journal_title：Scandinavian journal of rheumatology

authors： Bush KA,Walker JS,Frazier J,Kirkham BW

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of the essential omega-6 fatty acid Gammalinolenic acid (GLA) on fatigue associated with primary Sjögren's syndrome. METHODS:Ninety patients with primary Sjögren's syndrome (with or without signs of autoimmunity) entered a 6-month double blind placebo-controlled randomised trial with...

journal_title：Scandinavian journal of rheumatology

authors： Theander E,Horrobin DF,Jacobsson LT,Manthorpe R

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To study the frequence of deltoideal proximal insertion enthesitis (DPIE) in patients affected with spondyloarthritis (SpA) and to evaluate its clinical, sonographic and radiological characteristics. METHODS:A retrospective study of clinical, sonographic and radiological examinations of the shoulders of 100 ...

journal_title：Scandinavian journal of rheumatology

authors： Falsetti P,Frediani B,Filippou G,Acciai C,Baldi F,Storri L,Bisogno S,Marcolongo R

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To determine if calprotectin is predictive for outcome in patients with rheumatoid arthritis (RA). METHODS:Fifty six RA in-patients with variable disease duration were prospectively followed for five years. Clinical and laboratory data were collected to assess disease activity. Health Assessment Questionnair...

journal_title：Scandinavian journal of rheumatology

authors： Madland TM,Hordvik M,Haga HJ,Jonsson R,Brun JG

更新日期：2002-01-01 00:00:00

abstract：:No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-...

journal_title：Scandinavian journal of rheumatology

authors： Mayordomo L,Marenco JL,Gomez-Mateos J,Rejon E

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. METHODS:Validated baseline and follow-up QoL questionnaires were completed by...

journal_title：Scandinavian journal of rheumatology

authors： Yeomans N,Wilson I,Långström G,Hawkey C,Naesdal J,Walan A,Wiklund I

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The study was done to determine whether the new SCORE (Simple Calculated Osteoporosis Risk Estimation) index might reduce the utilization of bone mineral density (BMD) measurement. METHODS:989 consecutive patients who were referred by a range of physicians for BMD assessments at one of two clinics had a SCO...

journal_title：Scandinavian journal of rheumatology

authors： Russell AS,Morrison RT

更新日期：2001-01-01 00:00:00

abstract：:ANA testing by immunofluorescence technique (F-ANA) is nowadays still performed in much the same way as 45 years ago when the test was introduced. Due to its low specificity the F-ANA test has a poor predictive value for systemic autoimmune diseases and in addition has proven difficult to standardise. In the meantime,...

journal_title：Scandinavian journal of rheumatology

authors： Nossent H,Rekvig OP

更新日期：2001-01-01 00:00:00

abstract：:Raynaud's phenomenon, digital ischemia, antinuclear antibodies and anticardiolipin antibodies are uncommon features of malignancy. The association of all of these in a patient with malignancy has not previously been reported. We describe a 52 year old woman with non small-cell carcinoma of the lung who also had Raynau...

journal_title：Scandinavian journal of rheumatology

authors： Vaidya S,Logan JW

更新日期：2001-01-01 00:00:00

abstract：:Based on open studies. D-penicillamine (DPA) has been used for the treatment of systemic sclerosis (SSc) but we believe the controlled trial of this drug in SSc does not support its use to treat this disease. Open trials are inevitably biased by selection bias and randomized, blinded, controlled studies are required t...

journal_title：Scandinavian journal of rheumatology

authors： Furst DE,Clements PJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the correlation between antiphosphatidylethanolamine antibodies (aPE) and some antiphospholipid antibodies (aPL)-related clinical manifestations in patients with systemic lupus erythematosus (SLE). METHODS:Patients with SLE (n=217) were tested for the presence of aPE, anticardiolipin antibodies (...

journal_title：Scandinavian journal of rheumatology

authors： Balada E,Ordi-Ros J,Paredes F,Villarreal J,Mauri M,Vilardell-Tarrés M

更新日期：2001-01-01 00:00:00

abstract：:The occurrence of both multiple sclerosis (MS) and systemic lupus erythematosus (SLE) has previously been described in several members within the same family and in twins of successive generations, but the finding of both diseases in one patient is a great rarity. We here report on a rare coexistence of MS and SLE bot...

journal_title：Scandinavian journal of rheumatology

authors： Hietaharju A,Peltola J,Seppä J,Luukkainen R,Dastidar P

更新日期：2001-01-01 00:00:00

abstract：:Fifty consecutive patients with RA and clinical wrist synovitis were randomly allocated to either receive an injection of glucocorticoid into the radiocarpal joint or have the same amount of drug divided into the radiocarpal and midcarpal joints. Inferior radioulnar joint synovitis was treated with extra steroid injec...

journal_title：Scandinavian journal of rheumatology

authors： Koski JM,Hermunen H

更新日期：2001-01-01 00:00:00

abstract：:The evidence base for treatment of systemic vasculitis is reviewed in this article. Accurate diagnosis and evaluation of disease status is crucial to the appropriate management of these cases and disease status should be employed as a means of staging so that appropriate therapy can be offered tailored to the individu...

journal_title：Scandinavian journal of rheumatology

authors： Luqmani RA

更新日期：2000-01-01 00:00:00

abstract：:Involvement of brain parenchyma or meninges in ANCA-associated small-vessel vasculitis such as Wegener's granulomatosis (WG) is not uncommon. In contrast, involvement of the pituitary is exceedingly rare with only a few cases reported so far. The diagnosis is usually made on the basis of imaging techniques and abnorma...

journal_title：Scandinavian journal of rheumatology

authors： Woywodt A,Knoblauch H,Kettritz R,Schneider W,Göbel U

更新日期：2000-01-01 00:00:00

abstract：:In this retrospective analysis of the DMARD CPH 82 in 44 Icelandic patients with severe refractory arthritis, clinical tolerance was good and serious side effects absent, although the majority were using the drug in combination with other DMARDS. Side effects leading to discontinuation were seen in 16% and the three y...

journal_title：Scandinavian journal of rheumatology

authors： Gudmundsdóttir ES,Jónsson H

更新日期：2000-01-01 00:00:00

abstract：:Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and serositis. Typical attacks of FMF last 3 to 5 days. Fever and myalgia are not always improved by colchicine therapy and sometimes require steroid therapy. We present two cases of severe prolonged febrile myalgia where steroid therapy...

journal_title：Scandinavian journal of rheumatology

authors： Odabas AR,Cetinkaya R,Selcuk Y,Kaya H

更新日期：2000-01-01 00:00:00

abstract：:Case 1. A 20-year-old woman presented 4 weeks post-partum with widespread symmetrical inflammatory polyarthropathy with marked synovitis. Investigations revealed grossly raised CRP with negative immunology screen. A few days before presentation she saw her general practitioner with left-sided mastitis, which then deve...

journal_title：Scandinavian journal of rheumatology

authors： Al-Allaf AW,Pullar T

更新日期：2000-01-01 00:00:00

abstract：:Protracted febrile myalgia (PFM) is a rare form of vasculitic disease that affects patients with familial Mediterranean fever (FMF). Mutation analysis performed in 15 patients who suffered from this disorder showed that 9 of the 15 patients were homozygous for M694V. FMF in these 9 patients was associated with more se...

journal_title：Scandinavian journal of rheumatology

authors： Sidi G,Shinar Y,Livneh A,Langevitz P,Pras M,Pras E

更新日期：2000-01-01 00:00:00

abstract：:To investigate whether the therapeutic effect of etidronate is affected by the time of ingestion we have retrospectively studied 110 osteoporotic patients. They had been taking etidronate according to the manufacturer's instructions for a mean duration of 2.6 years either on waking (n=47), on retiring (n=47), or durin...

journal_title：Scandinavian journal of rheumatology

authors： Cook GJ,Blake GM,Fogelman I

更新日期：2000-01-01 00:00:00

abstract：:The aim of the present study was to assess the T cell cytokines IFN-gamma, IL-2, IL-4 and IL-5 in labial salivary glands (LSG) in Sjögren's syndrome (SS) and healthy controls using RT-PCR and immunohistochemistry. IFN-gamma is always or almost always produced in SS and in healthy controls. IL-2 was also found in some ...

journal_title：Scandinavian journal of rheumatology

authors： Konttinen YT,Kemppinen P,Koski H,Li TF,Jumppanen M,Hietanen J,Santavirta S,Salo T,Larsson A,Hakala M,Sorsa T

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility of magnetic resonance imaging (MRI)-guided high power focused ultrasound (FUS) to perform synovectomy noninvasively. METHODS:Five New Zealand white male rabbit knees with experimentally induced arthritis underwent MRI-guided thermal surgery by high power (60 W/10 s) sonication....

journal_title：Scandinavian journal of rheumatology

authors： Foldes K,Hynynen K,Shortkroff S,Winalski CS,Collucci V,Koskinen SK,McDannold N,Jolesz F

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To investigate the molecular and biochemical profile of skeletal muscle mitochondria of patients with isolated polymyalgia rheumatica (PMR). PATIENTS AND METHODS:We included patients with a recent diagnosis of PMR and as control healthy individuals submitted to orthopedic surgery. Skeletal muscle was obtaine...

journal_title：Scandinavian journal of rheumatology

authors： Miró O,Jarreta D,Casademont J,Barrientos A,Rodríguez B,Gómez M,Nunes V,Urbano-Márquez A,Cardellach F

更新日期：1999-01-01 00:00:00

abstract：:Perinatal outcome in infants of women with rheumatic disease notified between 1967 95 to the Medical Birth Registry of Norway was compared to women without such disease. Logistic regression provided odds ratios for associations between rheumatic disease and perinatal outcome for 3 time periods: 1967-76, 1977-86, and 1...

journal_title：Scandinavian journal of rheumatology

authors： Skomsvoll JF,Ostensen M,Irgens LM,Baste V

更新日期：1999-01-01 00:00:00

abstract：:YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL-40 in osteoarthriti...

journal_title：Scandinavian journal of rheumatology

authors： Volck B,Ostergaard K,Johansen JS,Garbarsch C,Price PA

更新日期：1999-01-01 00:00:00

abstract：:The associations between the lumbar and femoral bone mineral and several body constitutional, lifestyle, and disease related variables were studied in 111 children with juvenile chronic arthritis (JCA) by factor and multiple linear regression analyses. In addition to the measurement of bone mineral density (BMD), bone...

journal_title：Scandinavian journal of rheumatology

authors： Kotaniemi A,Savolainen A,Kröger H,Kautiainen H,Isomäki H

更新日期：1999-01-01 00:00:00

abstract：:Allergic disorders have been described in a variety of connective tissue disorders. Although an association between allergy and primary Sjögren's syndrome has been suggested, it has not been well documented. The purpose of this study was to analyze the prevalence of several types of allergic disorders in a cohort of p...

journal_title：Scandinavian journal of rheumatology

authors： Tishler M,Paran D,Yaron M

更新日期：1998-01-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorr...

journal_title：Scandinavian journal of rheumatology

authors： Lai RS,Lin SL,Lai NS,Lee PC

更新日期：1998-01-01 00:00:00

abstract：:Cytokines are signalling glycoproteins mediating acute inflammation, chronic inflammation, and connective tissue destruction. The present study was designed to characterize the profile of cytokine message in normal human articular cartilage and from patients with rheumatoid arthritis (RA) and osteoarthritis (OA), by m...

journal_title：Scandinavian journal of rheumatology

authors： Leistad L,Ostensen M,Faxvaag A

更新日期：1998-01-01 00:00:00

abstract：:The distribution of messenger RNA coding for substance P receptor (NK1) in rheumatoid synovia and the relationship between signal intensity of NK1 mRNA and clinical parameters of disease activity were investigated. The synovia from 10 patients with rheumatoid arthritis (RA) and 7 patients with osteoarthritis was inves...

journal_title：Scandinavian journal of rheumatology

authors： Sakai K,Matsuno H,Tsuji H,Tohyama M

更新日期：1998-01-01 00:00:00

abstract：:The chronic inflammatory response to abrasion particles from total hip replacement (THR) is believed to cause osteolysis and to contribute to prosthetic loosening. The expression of interleukin-11(IL-11) and its major cellular sources in the interface and pseudocapsular tissues obtained from total hip revisions perfor...

journal_title：Scandinavian journal of rheumatology

authors： Xu JW,Li TF,Partsch G,Ceponis A,Santavirta S,Konttinen YT

更新日期：1998-01-01 00:00:00

abstract：:Pulmonary hemorrhage is a rare, but serious manifestation of systemic lupus erythematosus (SLE). Herein, we report 13 cases of severe pulmonary hemorrhage in SLE. Hemoptysis was present in 11 patients. All thirteen patients had active nephritis and were in the stage of nephrotic syndrome. A majority of the patients ha...

journal_title：Scandinavian journal of rheumatology

authors： Liu MF,Lee JH,Weng TH,Lee YY

更新日期：1998-01-01 00:00:00

abstract：:Psychological and emotional status was assessed in 36 patients with systemic lupus erythematosus (SLE) with the General Health Questionnaire-30 (GHQ-30) and Minnesota Multiphasic Personality Inventory (MMPI) questionnaires. The two tests were found to measure different aspects of psychological functioning. More than 5...

journal_title：Scandinavian journal of rheumatology

authors： Waterloo K,Omdal R,Husby G,Mellgren SI

更新日期：1998-01-01 00:00:00

abstract：:The correlation among the various markers of activated T cells (soluble interleukin 2 receptor (sIL-2R), HLA-DR+ and HLA-DP+ T cells, proliferating cell nuclear antigen (PCNA) positive lymphocytes) were examined in patients with systemic lupus erythematosus (SLE), and related to the cell cycle. The concentration of sI...

journal_title：Scandinavian journal of rheumatology

authors： Tokano Y,Morimoto S,Hishikawa T,Murashima A,Abe M,Sekigawa I,Takasaki Y,Hashimoto H,Okumura K,Shirai T,Hirose S

更新日期：1997-01-01 00:00:00

abstract：:Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given...

journal_title：Scandinavian journal of rheumatology

authors： Schirmer M,Mur E,Pfeiffer KP,Thaler J,Konwalinka G

更新日期：1997-01-01 00:00:00

abstract：:T cell receptor (V beta) use in the response to type II collagen and cartilage proteoglycans was analysed in peripheral blood and synovial fluid T cells from RA patients. T cells from RA patients with an immune response to connective tissue antigens, and paired PB and SF samples were stimulated in vitro with type II c...

journal_title：Scandinavian journal of rheumatology

authors： Cuesta IA,Sud S,Song Z,Affholter JA,Karvonen RL,Fernández-Madrid F,Wooley PH

更新日期：1997-01-01 00:00:00

abstract：:Presenting symptoms in polymyalgia rheumatica (PMR) may be atypical. We report herein two old females who developed a bilateral carpal tunnel syndrome several months before the typical symptoms of PMR appeared. In both patients the diagnosis of PMR was overlooked and a surgical release of the median nerve was performe...

journal_title：Scandinavian journal of rheumatology

authors： Herrera B,Sanmartí R,Ponce A,Lopez-Soto A,Muñoz-Gómez J

更新日期：1997-01-01 00:00:00